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:: Volume 21, Number 1 (Spring 2015) ::
Horizon Med Sci 2015, 21(1): 45-51 Back to browse issues page
Hypolipidemic Activity of Aqueous Extract of Turnip (Brassica rapa) Root in Hyperlipidemic Rats
saeed vafaei nejad1, elham serki2, mohammad hassanpour fard3, mehran hosseini *4
1- BSc Anatomy Department, Medicine Faculty, Birjand University of Medical Sciences (BUMS), Birjand, Iran
2- BSc Biochemistry Department, Medicine Faculty, Birjand University of Medical Sciences (BUMS), Birjand, Iran
3- PhD Physiology & Pharmacology Department, Medicine Faculty, Birjand University of Medical Sciences (BUMS), Birjand, Iran
4- BSc Experimental Medicine Research Center, Deputy of Research & Technology, Birjand University of Medical Sciences (BUMS), Birjand, Iran , mehranhosseiny@yahoo.co.in
Abstract:   (1060 Views)

Aims: Turnip is one of the most consumed medicinal plants that seem to have advantageous efficacy on hyperlipidemia. The present work was undertaken to evaluate the hypolipidemic activity of aqueous extract of Brassica rapa root on hyperlipidemic rats. Materials & Methods: In this experimental study 40 male Wistar rats were divided into 5 equal groups normal control, hyperlipidemic control (1ml normal saline once a day), Atorvastatin (10mg/kg of body weight per day) and aqueous extract of Brassica rapa root groups (200 and 400mg/kg of body weight per day) were treated for 10 days. After 18h fasting in 11th day, hyperlipidemia was induced by a single intraperitoneal (IP) injection of triton WR1339 (300mg/kg of body weight) in all groups except normal control. 24 hours after injection, blood collection was done and plasma analyzed for lipid profiles. Data was compared between group s by ANOVA and Tukey tests in SPSS 18 software. Findings: Aqueous extract of Brassica rapa root inhibited the elevation of plasma total cholesterol level at the dose of 200mg/kg of body weight. The extract also decreased LDL cholesterol and triglyceride levels in hyperlipidemic rats significantly but in compare to normal control group these levels were significantly high (p<0.05). Conclusion: The consumption of turnip may act as a potent antihyperlipidemic nutrient for patients with dyslipidemia, cardiovascular and diabetes diseases.

Keywords: Hypolipidemic Agents [http://www.ncbi.nlm.nih.gov/mesh/68000960], Turnip [http://www.ncbi.nlm.nih.gov/mesh/68029688], Plant Roots [http://www.ncbi.nlm.nih.gov/mesh/68018517], Rats [http://www.ncbi.nlm.nih.gov/mesh/68051381]
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Type of Study: Original | Subject: Laboratory Medicine
Received: 2014/09/11 | Accepted: 2015/01/31 | Published: 2015/03/17
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DOI: 10.18869/acadpub.hms.21.1.45


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vafaei nejad S, serki E, hassanpour fard M, hosseini M. Hypolipidemic Activity of Aqueous Extract of Turnip (Brassica rapa) Root in Hyperlipidemic Rats. Horizon Med Sci . 2015; 21 (1) :45-51
URL: http://hms.gmu.ac.ir/article-1-2044-en.html
Volume 21, Number 1 (Spring 2015) Back to browse issues page
مجله علمی پژوهشی افق دانش The Horizon of Medical Sciences
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