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Aims: Purslane (Portulaca oleracea L) is Iranian native and one of the most important vegetables in herbal medicine that has many properties such as anti-scurvy, treating intractable cough, blood purifier, a sedative for thirst, anti-fever, useful in healing burns as well as anti-inflammatory and analgesic effects. The aim of this study was to investigate the effects of purslane herb extract on electrophoretic pattern of blood protein in mice. Methods: In this experimental study, to investigate the effects of extract of purslane on the blood protein levels in mice, 40 adult mice of Balb/C were selected and divided randomly into five groups of eight which were used for 20 days during the experiment. The groups included control and placebo, and three experimental groups receiving Hydro-alcoholic extract of Purslane were prepared in 50,100 and 200 mg/kg/doses of body weight. At the end of the experiment, all mice were bled and the immune system proteins and total protein levels were measured. The data were analyzed using one-way ANOVA and Duncan. Results: Our results indicated that a significant decrease in albumin concentration at 50 mg/kg can be seen. The highest amount of total protein and concentration of alpha-2 belong to the group of 100mg/kg extract dose (P<0.05). Conclusion: It seems that purslane extract without antigenic stimulation could strengthen the immune system. On the other hand, the increase in serum globulins means that the purslane extract can have increasing impact on the activity of the immune system in mice.

Keywords: Serum, Blood Protein Electrophoresis, Portulaca, Mice

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