Volume 19, Issue 2 (Summer 2013)                   Horizon Med Sci 2013, 19(2): 67-70 | Back to browse issues page

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Shahraki M.R., Mirshekari H., Khamar Moghadam S.. Effect of Short-time Consumption of Oral Magnesium Sulfate on Blood Glucose and Serum Lipids in Streptozotocin-induced Diabetic Male Rats. Horizon Med Sci. 2013; 19 (2) :67-70
URL: http://hms.gmu.ac.ir/article-1-1701-en.html
1- Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , m_shahrakim@zaums.ac.ir
Abstract:   (5256 Views)

Aims: Diabetes mellitus is a metabolic disorder which caused by hyperglycemia. Since the serum magnesium level plays an important role in obvious diabetes side effects, the aim of this survey was to evaluate the effect of oral magnesium sulfate administration on blood glucose and serum lipids in streptozotocin-induced diabetic male rats.

Methods: This experimental study was performed on 32 Wistar-Albino male rats, which were weighed between 200-250gr. One half of animals were given intra peritoneal injection of 50mg/kg streptozotocin solution which was prepared in sodium citrate buffer. Rats were divided into two healthy A and B groups and two diabetic C and D groups. A and C groups’ samples were feed by rodent's diet and tap water but B and D groups’ samples received normal diet and water containing 10mg/ml magnesium sulfate during the experiment. At the end of the experiment, serum glucose and lipoprotein profile of rats were measured. Obtained data were analyzed by SPSS 17 using ANOVA and Tukey tests.

Results: Blood glucose, serum Triglyceride and LDL level in group D were significantly decreased compared to those of group C, but there was no significant difference in the HDL and total cholesterol level between groups C and D.

Conclusion: Oral magnesium sulfate consumption cause in blood glucose decreasing and serum lipoprotein profile improvement in streptozotocin-induced diabetic male rats.

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Type of Study: Original | Subject: Physiology
Received: 2013/01/8 | Accepted: 2013/07/16 | Published: 2013/07/16

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