Aims: Long-chain omega-3 fatty acids consumed through diet reduces the production of IL-1, IL-6, IL-4, TNF-α by different cells. Osteoporosis increases the risk of bone fractures, particularly in postmenopausal women . The aim of this study was to investigate the effects of canola in comparison to sunflower oil on serum inflammation markers in patients with osteoporosis.

Methods: In a randomized clinical trial, 40 osteoporotic of bone disease center of Shahid Beheshti University of Medical Sciences were selected by available sampling from September 2010 to November 2012. The patients were divided into two groups of canola and sunflower oil. The data were analyzed by SPSS 16 software by coupled and independent T tests.

Results: In sunflower oil group, systolic blood pressure reduced significantly (p=0.001). Serum vitamin D3 was also increased significantly in canola (p=0.03) and sunflower oil groups (p=0.042) at the end of the intervention period in comparison to baseline. Changes of IL-1, IL-4, IL-6, TNF-α level were not significant in the end of the intervention period in comparison to baseline in both groups.

Conclusion: The consumption of canola in comparison to sunflower oil, do not have any effect on reduction of inflammatory biomarkers in osteoporosic.