Aims: Exercise and physical activity are effective factors on serum level of homocysteine. C-creative protein (CRP) is a serum protein that is synthetized in liver and increasing of its production is a response to infectious diseases, inflammations and tissue traumas. The goal of the current research was to evaluate the short-time effect of acute exercise on the plasma levels of homocysteine and CRP in obese and non-obese women.

Methods: This quasi-experimental controlled pretest and posttest study was conducted in 20 to 30 year old women referred to sport physiology laboratory and 10 women with the lipid level of 35-45% were selected by random sampling method as test group. 10 female students with lipid level of 21-23% were selected as control group. Weight, fat percentage, waist hip ratio (WHR) and body mass index (BMI) of samples were measured before and after one session of acute exercise. Data were analyzed with paired T-test and covariance by using SPSS 16 software.

Results: As a result of one session of acute exercise, the homocysteine level were increased significantly in test group (p=0.02) and this increasing was not significant in control group (p=0.1). CRP levels were increased in both test (p=0.001) and control groups (p=0.0001). Homocysteine levels change after one session of acute exercise was significant between 2 groups (P=0.004) and increasing was more in test group. There was no significant difference between 2 groups according to CRP levels (p=0.62).

Conclusion: One session of acute exercise can elevate the serum levels of homocysteine and CRP in both obese and normal women.